Standard 6: Age Groups for Pediatric Trials

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Standard 6: age groups for pediatric trials.

It has long been an axiom in clinical pediatrics that “children are not just little adults.” It has also been recognized that there are many changes from birth through childhood and the adolescent years. However, the full implications of pediatric age groupings for health care and research are still not adequately understood. There is still much to be discovered about children’s biological and ...

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Empirical evaluation of age groups and age-subgroup analyses in pediatric randomized trials and pediatric meta-analyses.

BACKGROUND An important step toward improvement of the conduct of pediatric clinical research is the standardization of the ages of children to be included in pediatric trials and the optimal age-subgroups to be analyzed. METHODS We set out to evaluate empirically the age ranges of children, and age-subgroup analyses thereof, reported in recent pediatric randomized clinical trials (RCTs) and ...

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ژورنال

عنوان ژورنال: Pediatrics

سال: 2012

ISSN: 0031-4005,1098-4275

DOI: 10.1542/peds.2012-0055i